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I use an fstop lotus http://shop.fstopgear.com/us/product/mountain/lotus.html
Kind of expensive, but totally worth it. I’ve hiked with it, flown with it, loaded it down with more weight than it’s supposed to hold… It’s water resistant, you can get a rain cover for it, modular straps for tripod/camping gear, you can change the ICU inserts for different lens/camera combinations, or take the ICU out completely and just use it as a backpack. It also has rear-panel access to the camera compartment, which means if you dump it off on the muddy ground to get your camera out, your back stays nice and dry when you put it back on.
It’s got an internal frame, and a good waist strap which, if you are going to be hiking with anything more than 15-20lbs of camera gear I would highly recommend. The difference between the Fstop and the Lowepro Fastpack I upgraded from is that the Fstop seems to have actually been made with carrying decent amount of gear while hiking in mind – with the Fastpack, with the 30-35lbs of gear I usually haul when I’m on a trip (4 lenses, 1 camera, 13″ laptop, batteries, change of clothes, snacks, water, etc.) my shoulders would tend to get *really* sore while hiking. Not so with the Lotus. The only downside is the price…but if you think you’ll be mostly using it for travel and hiking, you really can’t do better.