I think so, @creative-click-photography. Increasing Detail would bring back some of the noise.
But you’re right, preserving detail in an image is generally what I want (preserving “the most detail as possible” is not always what I want, but generally speaking, yes).
After playing around a little more with some hideous-ISO-number images, it does seem like Detail does a very nice job of bringing back texture and detail without bringing back the noise. So yeah, it seems like moving it from 50 to something higher to even like 100 could be really good!
Every picture is different. Logan said it well, “find the happy middle number with as much detail as possible with as little noise as possible.”